Immunity Mediators in Intestinal Mucosa Hyperplasia and Up-Regulation of Innate IL-9 Promotes IL-13-Dependent Paneth Cell
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BAGGA et al LPA AND HUMAN MAST CELL DEVELOPMENT 1 Lysophosphatidic Acid Accelerates the Development of Human Mast Cells
BAGGA et al LPA AND HUMAN MAST CELL DEVELOPMENT 2 Mast cells (MCs) initiate immune responses from mucosal surfaces and perivascular spaces. Stem cell factor (SCF) regulates MC development and viability, but the role of innate serum factors in MC development is unexplored. Cultured cord blood-derived human MCs (hMCs) express mRNA transcripts for all four known receptors for lysophosphatidic acid...
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Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Undigested gliadin peptides induce innate and adaptive T cell-mediated immune responses. The major mediator of the stress and innate immune response to gliadin peptides (i.e., peptide 31-43, P31-43) is the cytokine interleukin-15 (IL-15). The role of epithelial growth...
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Correspondence to: Professor Y R Mahida, Institute of Infection, Immunity, and Inflammation, C Floor, West Block, Queen’s Medical Centre, Nottingham NG7 2UH, UK; Yash.Mahida@ Nottingham.ac.uk _________________________ I n this article, we discuss the current understanding of how the intestinal mucosa may exert control over luminal bacteria, and how intestinal inflammation could ensue when this ...
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The development of intestinal goblet cell hyperplasia/hypertrophy during nematode infection involves the Th2 cytokines IL-4 and IL-13 via STAT6 activation. This is thought to play an important role in host protective immunity against the infection. In this study we demonstrate that IL-4 and IL-13 up-regulate the specific goblet cell product trefoil factor-3 (TFF3) from the mucus-producing HT-29...
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Immune responses associated with intestinal nematode infections are characterized by the activation of T-helper 2 (Th2) cells. Previous studies demonstrated that during Trichinella spiralis infection, Th2 cells contribute to the development of intestinal muscle hypercontractility and to worm eviction from the gut, in part through signal transducer and activator of transcription factor 6 (Stat6)...
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تاریخ انتشار 2009